52022-31-8
Chemical Structure
Ambenonium dichloride tetrahydrate
Synonym(s): WIN 8077 dichloride tetrahydrate
- CAS No.: 52022-31-8
- Formula:C28H50Cl4N4O6
- Molecular Weight:680.53
IUPAC Name: 2,2'-(oxalylbis(azanediyl))bis(N-(2-chlorobenzyl)-N,N-diethylethan-1-aminium) chloride tetrahydrate
InChIKey: FFLYNBGKFQTWPI-UHFFFAOYSA-N
SMILES: O=C(NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)C(NCC[N+](CC)(CC)CC2=CC=CC=C2Cl)=O.[Cl-].[Cl-].O.O.O.O
Biological Activity: Ambenonium (WIN 8077) dichloride tetrahydrate is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride tetrahydrate inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2].
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Ambenonium dichloride tetrahydrate | Ambenonium (WIN 8077) dichloride tetrahydrate is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride tetrahydrate inhibits human AChE with an IC50 value of 0.7 nM (hAChE). | |||||||||||||||||||||
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- [1]. Hodge AS, et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol. 1992 May. 41(5):937-42. [Content Brief]
- [2]. Komloova M, et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett. 2011 Apr 15. 21(8):2505-9. [Content Brief]
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