BuChE-IN-7
BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things.
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- CAS. Nr.: 3041971-93-8
- Formel: C25H34N2O2
- Molecular Weight:394.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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hBCHE 40 nM (IC50) |
eqBCHE 80 nM (IC50) |
BuChE-IN-7 (compound (R)-29) (10 µM; 5 min) inhibits eqBuChE, hBuChE with IC50 values of 0.08 µM, 0.04 µM respectively[1].
BuChE-IN-7 (1, 10, 50 and 100 µM; 72 h) has hepatotoxicity in HepG2 cell line with an IC50 value of 2.85 µM. BuChE-IN-7 decreas the cell activity and shows weaker effect on CYP3A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BuChE-IN-7 (10 mg/kg; i.p.; once daily for 6 days) has insignificant improvement the learning defect caused by scopolamine in mice[1].
BuChE-IN-7 (15 mg/kg and 30 mg/kg; i.p.; single dose) significantly promotes cognition and improves situational and phobic memory of mice, showing preference for new things[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3041971-93-8
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Molecular Weight 394.55
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Formel C25H34N2O2
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SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BuChE-IN-7 Related Classifications
HY-152632 Related Classifications
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