438-60-8
438-60-8
Chemical Structure
Protriptyline
- CAS No.: 438-60-8
- Formula:C19H21N
- Molecular Weight:263.38
IUPAC Name: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
InChIKey: BWPIARFWQZKAIA-UHFFFAOYSA-N
SMILES: CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13
Biological Activity: Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].
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Protriptyline | Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease. | |||||||||||||||||||||
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Protriptyline-d3 | Protriptyline-d3 is deuterium labeled Protriptyline (HY-B0949). Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease. | |||||||||||||||||||||
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References
- [1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196.
- [2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. [Content Brief]
- [3]. Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261. [Content Brief]
Keywords
