Glutathione S-transferase Degrader
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EA-B2L
0 ImagesCat. No.: HY-169350CAS No.: 1354444-72-6EA-B2L is a GSTP degrader with a DC50 of 48 μM in HeLa cells. EA-B2L inhibits GSTP enzymatic activity, induces dose-dependent GSTP degradation via the ubiquitin-proteasome and autophagy pathways, and does not activate the 20S proteasome subunit. EA-B2L induces dose-dependent apoptosis in cancer cells, a process associated with GSTP degradation, caspase 3 activation, and PARP cleavage. EA-B2L exerts dose-dependent antiproliferative effects on cancer cells with high GSTP expression. EA-B2L can be used in the research of cervical cancer, lung cancer, and fibrosarcoma.
