2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutathione S-transferase
  5. Glutathione S-transferase Inducer

Glutathione S-transferase Inducer

Glutathione S-transferase Inducers (3):

Cat. No. Product Name Effect Purity
  • HY-160926
    16-Oxocafestol
    		Inducer 98.0%
    16-Oxocafestol enhances levels of glutathione S-transferase (GST) and tissue sulfhydryl in liver and in small bowel mucosa.
  • HY-132281
    16-Oxokahweol
    		Inducer
    16-Oxokahweol, a Kahweol (HY-N6258) derivative, is a glutathione S-transferase inducer.
  • HY-141439
    TBE 31
    		Inducer
    TBE 31 is an orally active Keap1/Nrf2 pathway activator and NQO1 inducer with a Dm value of 1.1 nM for NQO1. TBE 31 binds to cysteine residues of Keap1, inhibits ubiquitination and degradation of Nrf2, thereby activating the expression of ARE-dependent genes. TBE 31 induces cytoprotective enzymes including NQO1 and GST isoforms, promotes Nrf2 accumulation, and upregulates Nrf2-regulated genes related to antioxidation and lipid metabolism. TBE 31 inhibits pro-inflammatory responses, formation of AFB1-DNA adducts, endoplasmic reticulum stress, cell apoptosis (apoptosis), hepatic fibrosis, oxidative stress, and the expression of ChREBP. TBE 31 reduces the number of tumors in a mouse model of ultraviolet-induced skin carcinogenesis. TBE 31 enhances nerve growth factor-induced neurite outgrowth. TBE 31 attenuates LPS-induced serum TNF-α levels and immobility time in mice. TBE 31 can be used in research related to liver cancer, skin cancer, inflammation-related depression, and non-alcoholic steatohepatitis.