MAGL
Monoacylglycerol lipase
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty acids. MAGL links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid, the precursor of prostaglandins and other inflammatory mediators.
MAGL plays a critical role in lipid signalling: i) it is the major enzyme that controls the levels of 2-AG, an important lipid with various neuroprotective effects; ii) inactivation of MAGL induces an elevation in brain levels of 2-AG and a reduction of AA, a key precursor of pro-inflammatory prostaglandins, resulting in the reduction of neuroinflammation; iii) MAGL regulates the levels of free fatty acids (FFAs) in aggressive cancer cells, and this MAGL-promoted fatty acid network drives a number of pro-tumorigenic signalling pathways. MAGL is emerging as a promising drug target for various diseases.
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MAGL Related Products (86)
Related Products (86)
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MAGL-IN-6
0 ImagesCat. No.: HY-145945CAS No.: 2414320-29-7MAGL-IN-6 is a potent MAGL inhibitor with an IC50 of 4.71 nM. MAGL-IN-6 can be used for neurological disorders research (WO2020065613A1; example 234).
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ABD-1970
0 ImagesCat. No.: HY-124576CAS No.: 2010154-82-0
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MAGL-IN-15
0 ImagesCat. No.: HY-162305CAS No.: 2770967-08-1MAGL-IN-15 (Compound 6) is a MAGL inhibitor that can be used in the research of diseases and disorders related to the regulation of endocannabinoid system signaling activities.
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JJKK 048 (Standard)
0 ImagesCat. No.: HY-108613RCAS No.: 1515855-97-6JJKK 048 (Standard) is the analytical standard of JJKK 048 (HY-108613). This product is intended for research and analytical applications. JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain.
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JW 642 (Standard)
0 ImagesJW 642 (Standard) is the analytical standard of JW 642. This product is intended for research and analytical applications.
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MAGL-IN-11
0 ImagesCat. No.: HY-157042CAS No.: 3017151-84-4MAGL-IN-11 (compound 29) is a selective and reversible MAGL inhibitor. MAGL-IN-11 has the potential to study inflammation, cancer and antioxidants.
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MAGL-IN-1 (Standard)
0 ImagesCat. No.: HY-111538RCAS No.: 2324160-91-8MAGL-IN-1 (Standard) is the analytical standard of MAGL-IN-1 (HY-111538). This product is intended for research and analytical applications. MAGL-IN-1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL-IN-1 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL-IN-1 blocks MAGL in cell-based as well as in vivo assays.
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JZP-430 (Standard)
0 ImagesCat. No.: HY-101457RCAS No.: 1672691-74-5JZP-430 (Standard) is the analytical standard of JZP-430 (HY-101457). This product is intended for research and analytical applications. JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
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MAGL-IN-10
0 ImagesCat. No.: HY-157041CAS No.: 3017151-83-3
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MAGL-IN-12
0 ImagesCat. No.: HY-116143CAS No.: 1352011-38-1SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.
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MAGL-IN-19
0 ImagesCat. No.: HY-168145CAS No.: 2411570-42-6MAGL-IN-19 (compund 7o) is a highly potent and selective MAGL inhibitor.
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MAGL-IN-9
0 ImagesCat. No.: HY-157040CAS No.: 3017151-74-2MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC50 2.7 nM.
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Euphol (Standard)
0 ImagesEuphol (Standard) is the analytical standard of Euphol. This product is intended for research and analytical applications. Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain.
