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Referencia número: HY-163202

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MAGL-IN-13

MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL,with IC₅₀ values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. .

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₈H₂₄FN₅O₄
Peso molecular:513.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

MAGL-IN-13 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

rats Ca²⁺ channel (10 μM)^[1]

Ver todos los productos específicos de isoformas Calcium Channel :

In Vitro

MAGL-IN-13 (preincubated for 10 min at 37°C) inhibits mMAGL, hMAGL and rMAGL with IC₅₀ values of 0.026, 0.021 and 0.24 nM, respectively^[1].
MAGL-IN-13 inhibits MAGL irreversibly ^[1].
MAGL-IN-13 (0.1 and 1 μM) reveals selectivity towards MAGL^[1].
MAGL-IN-13 processes viability with IC₅₀ of 47 μM and low cytoxicity potential in mouse immortalized fibroblasts NIH3T3^[1].
MAGL-IN-13 inhibits rats Ca²⁺ channel at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

NIH 3T3
Concentration:

4, 13, 22, 34, 47, 60 μM
Incubation Time:

24 h
Result:

Exhibited low cytotoxic potential.

Cell Viability Assay^[1]

Cell Line:

NIH 3T3
Concentration:

4, 13, 22, 34, 47, 60 μM
Incubation Time:

24 h
Result:

Revealed an IC₅₀ of 47 μM.

In Vivo

MAGL-IN-13 (i.p.; 5 mg/kg) inhibits brain MAGL activity in a dose-dependent manner ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MAGL inhibition/adult male mice ^[1]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection
Result:

Inhibited brain MAGL activity.

Chemical Information

Peso molecular 513.52
Fòrmula C₂₈H₂₄FN₅O₄
SMILES

O=C1[C@@H]([C@H](N1C2CCN(CC2)C(N3N=NC4=C3C=CC=C4)=O)C5=CC6=C(C=C5)OCO6)C7=CC=C(C=C7)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Butini S et al., Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J Med Chem. 2024 Jan 19. doi: 10.1021/acs.jmedchem.3c01278. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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