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Cat. No.: HY-163202

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MAGL-IN-13

MAGL-IN-13 (compound (3R, 4S) - 5v) is a selective, irreversible inhibitor for MAGL,with IC₅₀ values of 0.026, 0.021 and 0.24 nM for mMAGL, hMAGL and rMAGL, respectively. MAGL-IN-13 can penetrant blood brain barrier. .

For research use only. We do not sell to patients.

Formula: C₂₈H₂₄FN₅O₄
Molecular Weight:513.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

MAGL-IN-13 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

rats Ca²⁺ channel (10 μM)^[1]

All Calcium Channel Isoforms :

In Vitro

MAGL-IN-13 (preincubated for 10 min at 37°C) inhibits mMAGL, hMAGL and rMAGL with IC₅₀ values of 0.026, 0.021 and 0.24 nM, respectively^[1].
MAGL-IN-13 inhibits MAGL irreversibly ^[1].
MAGL-IN-13 (0.1 and 1 μM) reveals selectivity towards MAGL^[1].
MAGL-IN-13 processes viability with IC₅₀ of 47 μM and low cytoxicity potential in mouse immortalized fibroblasts NIH3T3^[1].
MAGL-IN-13 inhibits rats Ca²⁺ channel at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Cytotoxicity Assay^[1]

View Protocol

Cell Line:

NIH 3T3
Concentration:

4, 13, 22, 34, 47, 60 μM
Incubation Time:

24 h
Result:

Exhibited low cytotoxic potential.

Cell Viability Assay^[1]

View Protocol

Cell Line:

NIH 3T3
Concentration:

4, 13, 22, 34, 47, 60 μM
Incubation Time:

24 h
Result:

Revealed an IC₅₀ of 47 μM.

In Vivo

MAGL-IN-13 (i.p.; 5 mg/kg) inhibits brain MAGL activity in a dose-dependent manner ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MAGL inhibition/adult male mice ^[1]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection
Result:

Inhibited brain MAGL activity.

Chemical Information

Molecular Weight 513.52
Formula C₂₈H₂₄FN₅O₄
SMILES

O=C1[C@@H]([C@H](N1C2CCN(CC2)C(N3N=NC4=C3C=CC=C4)=O)C5=CC6=C(C=C5)OCO6)C7=CC=C(C=C7)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Butini S et al., Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. J Med Chem. 2024 Jan 19. doi: 10.1021/acs.jmedchem.3c01278. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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