PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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BCN-PEG4-hydrazide
0 ImagesCat. No.: HY-133438CAS No.: 2741640-52-6BCN-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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(+)-Biotin-ONP
0 ImagesCat. No.: HY-130888CAS No.: 33755-53-2Synonyms: (+)-Biotin 4-nitrophenyl ester
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Boc-Aminoxy-PEG4-OH
0 ImagesCat. No.: HY-140423CAS No.: 918132-14-6
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DBCO-PEG1-acid
0 ImagesCat. No.: HY-140265CAS No.: 2228857-38-1
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N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid
0 ImagesCat. No.: HY-140247CAS No.: 2183440-70-0N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Ms-PEG2-MS
0 ImagesCat. No.: HY-140382CAS No.: 34604-52-9
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Benzyl-PEG2-CH2COOH
0 ImagesCat. No.: HY-135339CAS No.: 91842-53-4
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Tos-PEG6-C2-Boc
0 ImagesCat. No.: HY-133071CAS No.: 406213-75-0
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Fluorescein-PEG6-NHS ester
0 ImagesCat. No.: HY-141083CAS No.: 1818294-35-7
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Fluorescein-PEG5-NHS ester
0 ImagesCat. No.: HY-141082CAS No.: 2353409-62-6
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Methyltetrazine-PEG8-NHS ester
0 ImagesCat. No.: HY-141270CAS No.: 2183440-34-6
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Tos-PEG4-CH2-Boc
0 ImagesCat. No.: HY-42620CAS No.: 169751-73-9
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N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid
0 ImagesN-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
