PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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m-PEG4-MS
0 ImagesCat. No.: HY-130457CAS No.: 130955-37-2m-PEG4-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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TCO-PEG3-NHS ester
0 ImagesCat. No.: HY-141166CAS No.: 2141981-88-4
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Azido-PEG9-S-methyl ethanethioate
0 ImagesAzido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-S-methyl ethanethioate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Tri-(PEG1-C2-acid)
0 ImagesCat. No.: HY-140541CAS No.: 1381861-95-5
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Boc-NH-PEG10-CH2CH2NH2
0 ImagesCat. No.: HY-135930CAS No.: 1347704-59-9
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m-PEG7-4-nitrophenyl carbonate
0 ImagesCat. No.: HY-141405CAS No.: 678150-56-6
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DBCO-PEG6-amine
0 ImagesCat. No.: HY-140284CAS No.: 2353409-98-8
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PEG8-Tos
0 ImagesCat. No.: HY-130555CAS No.: 886469-23-4
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Amino-PEG9-amine
0 ImagesCat. No.: HY-140210CAS No.: 474082-35-4
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1,1,1-Trifluoroethyl-PEG2-azide
0 ImagesCat. No.: HY-140845CAS No.: 1835759-68-61,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bromoacetamido-PEG3-NH-Boc
0 ImagesCat. No.: HY-141200CAS No.: 1421933-39-2
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Ald-CH2-PEG3-azide
0 ImagesCat. No.: HY-130144CAS No.: 1002342-83-7Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ald-CH2-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Ald-CH2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
