2. PROTAC
  3. PROTAC Linkers
  4. Benzyl-PEG4-acid

Benzyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Benzyl-PEG4-acid Chemical Structure

Benzyl-PEG4-acid Chemical Structure

CAS No. : 127457-64-1

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Based on 1 publication(s) in Google Scholar

Benzyl-PEG4-acid Related Antibodies

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Description

Benzyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzyl-PEG4-acid Related Antibodies
Molecular Weight

312.36

Formula

C16H24O6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCC1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (320.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2014 mL 16.0072 mL 32.0143 mL
5 mM 0.6403 mL 3.2014 mL 6.4029 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2014 mL 16.0072 mL 32.0143 mL 80.0359 mL
5 mM 0.6403 mL 3.2014 mL 6.4029 mL 16.0072 mL
10 mM 0.3201 mL 1.6007 mL 3.2014 mL 8.0036 mL
15 mM 0.2134 mL 1.0671 mL 2.1343 mL 5.3357 mL
20 mM 0.1601 mL 0.8004 mL 1.6007 mL 4.0018 mL
25 mM 0.1281 mL 0.6403 mL 1.2806 mL 3.2014 mL
30 mM 0.1067 mL 0.5336 mL 1.0671 mL 2.6679 mL
40 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0009 mL
50 mM 0.0640 mL 0.3201 mL 0.6403 mL 1.6007 mL
60 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3339 mL
80 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0004 mL
100 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8004 mL
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Benzyl-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl-PEG4-acid127457-64-1PROTAC LinkersInhibitorinhibitorinhibit

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