PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
Azido-PEG3-O-NHS ester
0 ImagesCat. No.: HY-140768CAS No.: 2110448-98-9Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-O-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Bromoacetamide-PEG3-propargyl
0 ImagesCat. No.: HY-130942CAS No.: 932741-11-2Bromoacetamide-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamide-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
HOOC-PEG40000-NH2
0 ImagesCat. No.: HY-W1048547JPurity: 98.0%Synonyms: HOOC-PEG40000-AmineHOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc.
-
Hydroxy-PEG3-NHS
0 ImagesCat. No.: HY-130672CAS No.: 1807518-71-3
-
Acid-PEG6-C2-Boc
0 ImagesCat. No.: HY-140482CAS No.: 2093153-84-3
-
N-DBCO-N-bis(PEG2-C2-acid)
0 ImagesCat. No.: HY-140543CAS No.: 2110449-00-6
-
Azide-PEG2-MS
0 ImagesCat. No.: HY-140381CAS No.: 176520-23-3Azide-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG2-Ms is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
1,3-Bis-aminooxy propane dihydrochloride
0 ImagesCat. No.: HY-116924ACAS No.: 104845-82-1
-
Acid-PEG1-C2-Boc
0 ImagesCat. No.: HY-140479CAS No.: 2086689-08-7
-
Tos-PEG4-acid
0 ImagesCat. No.: HY-130417CAS No.: 1453117-42-4
-
m-PEG4-aldehyde
0 ImagesCat. No.: HY-140620CAS No.: 197513-96-5
-
Folate-PEG3-alkyne
0 ImagesCat. No.: HY-133496CAS No.: 1245285-73-7
-
Propargyl-PEG4-Boc
0 ImagesCat. No.: HY-140028CAS No.: 1355197-66-8
-
1,1,1-Trifluoroethyl-PEG2-propargyl
0 ImagesCat. No.: HY-140886CAS No.: 1835759-73-31,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
DBCO-PEG9-amine
0 ImagesCat. No.: HY-140285CAS No.: 2353409-99-9
