PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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NH2-PEG2-methyl acetate
0 ImagesCat. No.: HY-W096162CAS No.: 741235-80-3
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Bromo-PEG7-azide
0 ImagesCat. No.: HY-W096078CAS No.: 1056969-61-9Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-propargyl-PEG5
0 ImagesBis-propargyl-PEG5 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG5 is used for the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity. Bis-propargyl-PEG5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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N-Azido-PEG4-N-Boc-N-PEG3-Boc
0 ImagesCat. No.: HY-140566CAS No.: 2093152-85-1N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Azido-PEG4-N-Boc-N-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Aminooxy-PEG3-bromide
0 ImagesCat. No.: HY-140396CAS No.: 1895922-73-2
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Biotin-PEG3-propargyl
0 ImagesCat. No.: HY-138503CAS No.: 1421701-68-9
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Fmoc-NMe-PEG4-C2-acid
0 ImagesCat. No.: HY-140465CAS No.: 2170240-98-7
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DBCO-NHCO-PEG2-Biotin
0 ImagesCat. No.: HY-135939CAS No.: 2989400-08-8
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Azido-PEG6-C2-Boc
0 ImagesAzido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Fluorescein-PEG4-acid
0 ImagesCat. No.: HY-120368CAS No.: 1807518-76-8
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Azido-PEG8-TFP ester
0 ImagesCat. No.: HY-138437CAS No.: 1818294-49-3Azido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-TFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG5-triethoxysilane
0 ImagesCat. No.: HY-141408CAS No.: 2243566-42-7
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Ethyl acetate-PEG1
0 ImagesCat. No.: HY-W096086CAS No.: 2093-20-1
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S-acetyl-PEG4-alcohol
0 ImagesCat. No.: HY-141341CAS No.: 223611-42-5
