PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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m-PEG4-Tos
0 ImagesCat. No.: HY-114661CAS No.: 62921-76-0m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277).
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Aminooxy-PEG3-C2-thiol
0 ImagesCat. No.: HY-134512CAS No.: 1200365-63-4
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Azido-PEG4-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-140149CAS No.: 2055024-64-9Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG11-acid
0 Imagesm-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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HS-PEG5000-NH2 hydrochloride
0 ImagesCat. No.: HY-168937APurity: 98.0%HS-PEG5000-NH2 hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels.
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TLR4-IN-C34-C2-amide-C6-OH
0 ImagesCat. No.: HY-145245Purity: 99.62%TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
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Acid-PEG2-ethyl propionate
0 ImagesCat. No.: HY-W096144CAS No.: 886362-90-9
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Chloroacetamido-PEG4-C2-Boc
0 ImagesCat. No.: HY-130470CAS No.: 1365655-90-8
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Hydroxy-PEG3-MS
0 ImagesCat. No.: HY-W096069CAS No.: 139115-89-2
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S-acetyl-PEG4-Boc
0 ImagesCat. No.: HY-141347CAS No.: 1818294-26-6
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Boc-N-PEG5-C2-NHS ester
0 ImagesCat. No.: HY-126381CAS No.: 2055040-78-1
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DNP-PEG4-alcohol
0 ImagesCat. No.: HY-140618CAS No.: 1807520-99-5
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Fmoc-aminooxy-PEG12-NHS ester
0 ImagesCat. No.: HY-140442CAS No.: 2765338-86-9
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Azido-PEG2-C1-Boc
0 ImagesCat. No.: HY-140793CAS No.: 251564-45-1Azido-PEG2-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
