2. PROTAC
  3. PROTAC Linkers
  4. FA-PEG5-Mal

FA-PEG5-Mal  (Synonyms: Folic acid-PEG5-Mal)

Cat. No.: HY-132070 Purity: 99.46%
COA Handling Instructions

Molarity Calculator

FA-PEG5-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

FA-PEG5-Mal Chemical Structure

FA-PEG5-Mal Chemical Structure

Size Price Stock Quantity
1 mg USD 200 In-stock
5 mg USD 450 In-stock
10 mg USD 720 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

FA-PEG5-Mal Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FA-PEG5-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FA-PEG5-Mal Related Antibodies
Molecular Weight

783.78

Formula

C35H45N9O12
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(N=C(N1)N)N=CC(CNC3=CC=C(C=C3)C(N[C@@H](CCC(NCCOCCOCCOCCOCCOCCN4C(C=CC4=O)=O)=O)C(O)=O)=O)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2759 mL 6.3793 mL 12.7587 mL
5 mM 0.2552 mL 1.2759 mL 2.5517 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2759 mL 6.3793 mL 12.7587 mL 31.8967 mL
5 mM 0.2552 mL 1.2759 mL 2.5517 mL 6.3793 mL
10 mM 0.1276 mL 0.6379 mL 1.2759 mL 3.1897 mL
15 mM 0.0851 mL 0.4253 mL 0.8506 mL 2.1264 mL
20 mM 0.0638 mL 0.3190 mL 0.6379 mL 1.5948 mL
25 mM 0.0510 mL 0.2552 mL 0.5103 mL 1.2759 mL
30 mM 0.0425 mL 0.2126 mL 0.4253 mL 1.0632 mL
40 mM 0.0319 mL 0.1595 mL 0.3190 mL 0.7974 mL
50 mM 0.0255 mL 0.1276 mL 0.2552 mL 0.6379 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5316 mL
80 mM 0.0159 mL 0.0797 mL 0.1595 mL 0.3987 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3190 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FA-PEG5-Mal Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FA-PEG5-MalFolic acid-PEG5-MalPROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FA-PEG5-Mal
Cat. No.:
HY-132070
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.