PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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5-Hydroxypentanenitrile
0 ImagesCat. No.: HY-W001265CAS No.: 2427-16-9
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1,8-Diiodooctane
0 ImagesCat. No.: HY-W133862CAS No.: 24772-63-2
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trans-4-(Aminomethyl)cyclohexanemethanol
0 ImagesCat. No.: HY-W025986CAS No.: 17879-23-1
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5-Iodopentan-1-ol
0 ImagesCat. No.: HY-W192952CAS No.: 67133-88-4Synonyms: 5-iodo-1-pentanol
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3-(Methylamino)propanoic acid
0 ImagesCat. No.: HY-W076705CAS No.: 2679-14-3
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Di-tert-butyl succinate
0 ImagesCat. No.: HY-W106738CAS No.: 926-26-1
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Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz
0 ImagesCat. No.: HY-45669CAS No.: 2264011-97-2Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Cbz can be used in the synthesis of the Deruxtecan.
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Amino-PEG4-CH2COOH
0 ImagesCat. No.: HY-130524CAS No.: 195071-49-9Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Bis-aminooxy-PEG2
0 ImagesCat. No.: HY-140408CAS No.: 98627-71-5
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t-Boc-Aminooxy-PEG5-azide
0 ImagesCat. No.: HY-140434CAS No.: 2250216-95-4t-Boc-Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. t-Boc-Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Mal-N-bis(PEG2-acid)
0 ImagesCat. No.: HY-140529CAS No.: 2110449-02-8
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N-(Azido-PEG2)-N-Boc-PEG4-acid
0 ImagesCat. No.: HY-140525CAS No.: 2093153-82-1N-(Azido-PEG2)-N-Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG7-azide
0 ImagesAzido-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Tos-PEG5-C2-Boc
0 ImagesCat. No.: HY-133070CAS No.: 850090-10-7
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m-PEG24-Mal
0 ImagesCat. No.: HY-140984CAS No.: 2579693-28-8
