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Cat. No.: HY-W076705

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3-(Methylamino)propanoic acid

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3-(Methylamino)propanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Purity: ≥97.0%
CAS No.: 2679-14-3
Formula: C₄H₉NO₂
Molecular Weight:103.12

Storage:

RT, protect from light.

In solvent -80°C, 1 year , -20°C, 6 months

3-(Methylamino)propanoic acid Chemical Structure

CAS No.: 2679-14-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

3-(Methylamino)propanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

All PROTAC Linkers Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	6.55 μM Compound: 25	Reduction of propionyl-CoA in human hepatocytes derived from propionic acidemia patient pretreated for 30 mins followed by 13C-isoleucine addition and measured after 1 hr by MS/MS analysis Reduction of propionyl-CoA in human hepatocytes derived from propionic acidemia patient pretreated for 30 mins followed by 13C-isoleucine addition and measured after 1 hr by MS/MS analysis	[PMID: 33848153]

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E278 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.