2. PROTAC
  3. PROTAC Linkers
  4. HO-PEG14-OH

HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

HO-PEG14-OH Chemical Structure

HO-PEG14-OH Chemical Structure

CAS No. : 1189112-05-7

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100 mg USD 120 In-stock
250 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

HO-PEG14-OH Related Antibodies

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Description

HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HO-PEG14-OH Related Antibodies
Molecular Weight

634.75

Formula

C28H58O15
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (157.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5754 mL 7.8771 mL 15.7542 mL
5 mM 0.3151 mL 1.5754 mL 3.1508 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5754 mL 7.8771 mL 15.7542 mL 39.3856 mL
5 mM 0.3151 mL 1.5754 mL 3.1508 mL 7.8771 mL
10 mM 0.1575 mL 0.7877 mL 1.5754 mL 3.9386 mL
15 mM 0.1050 mL 0.5251 mL 1.0503 mL 2.6257 mL
20 mM 0.0788 mL 0.3939 mL 0.7877 mL 1.9693 mL
25 mM 0.0630 mL 0.3151 mL 0.6302 mL 1.5754 mL
30 mM 0.0525 mL 0.2626 mL 0.5251 mL 1.3129 mL
40 mM 0.0394 mL 0.1969 mL 0.3939 mL 0.9846 mL
50 mM 0.0315 mL 0.1575 mL 0.3151 mL 0.7877 mL
60 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6564 mL
80 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4923 mL
100 mM 0.0158 mL 0.0788 mL 0.1575 mL 0.3939 mL
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HO-PEG14-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HO-PEG14-OH1189112-05-7PROTAC LinkersInhibitorinhibitorinhibit

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