2. PROTAC
  3. PROTAC Linkers
  4. HO-PEG17-OH

HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

HO-PEG17-OH Chemical Structure

HO-PEG17-OH Chemical Structure

CAS No. : 351342-04-6

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100 mg USD 185 In-stock
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Based on 1 publication(s) in Google Scholar

HO-PEG17-OH Related Antibodies

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Description

HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HO-PEG17-OH Related Antibodies
Molecular Weight

766.91

Formula

C34H70O18
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (130.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3039 mL 6.5197 mL 13.0393 mL
5 mM 0.2608 mL 1.3039 mL 2.6079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3039 mL 6.5197 mL 13.0393 mL 32.5984 mL
5 mM 0.2608 mL 1.3039 mL 2.6079 mL 6.5197 mL
10 mM 0.1304 mL 0.6520 mL 1.3039 mL 3.2598 mL
15 mM 0.0869 mL 0.4346 mL 0.8693 mL 2.1732 mL
20 mM 0.0652 mL 0.3260 mL 0.6520 mL 1.6299 mL
25 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3039 mL
30 mM 0.0435 mL 0.2173 mL 0.4346 mL 1.0866 mL
40 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8150 mL
50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6520 mL
60 mM 0.0217 mL 0.1087 mL 0.2173 mL 0.5433 mL
80 mM 0.0163 mL 0.0815 mL 0.1630 mL 0.4075 mL
100 mM 0.0130 mL 0.0652 mL 0.1304 mL 0.3260 mL
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HO-PEG17-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HO-PEG17-OH351342-04-6PROTAC LinkersInhibitorinhibitorinhibit

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