Azido-PEG9-S-methyl ethanethioate

Name: Azido-PEG9-S-methyl ethanethioate
Brand: MedChemExpress
SKU: HY-132094
Rating: 4.5 (1 reviews)

Cat. No.: HY-132094 Pureza: 98.18%: Ficha de datos
COA

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Azido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-S-methyl ethanethioate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azido-PEG9-S-methyl ethanethioate Estructura química

No. CAS : 2148986-33-6

Tamaño	Stock	Cantidad
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Azido-PEG9-S-methyl ethanethioate:

Ambrisentan-d₁₀ In-stock

Recomendaciones destacadas

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Azido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Azido-PEG9-S-methyl ethanethioate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

541.66

Fòrmula

C₂₂H₄₃N₃O₁₀S

No. CAS

2148986-33-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(SCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 98.18%

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Ficha de datos (261 KB) SDS (251 KB)

COA (238 KB) HNMR (262 KB) RP-HPLC (249 KB) LCMS (92 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]