PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Ethyl 5-chloropentanoate
0 ImagesCat. No.: HY-W194311CAS No.: 2323-81-1
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NH2-PEG7-C-COOH
0 ImagesCat. No.: HY-W401256CAS No.: 177580-10-8
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MS-PEG3-O-MS
0 ImagesCat. No.: HY-W151570CAS No.: 80322-82-3
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(4-Bromobutyl)boronic acid
0 ImagesCat. No.: HY-W317565CAS No.: 61632-72-2
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NH2-PEG6-C1-Boc
0 ImagesCat. No.: HY-135918CAS No.: 297162-50-6
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1,4-Bis((tetrahydrofuran-2-yl)oxy)butane
0 ImagesCat. No.: HY-W419902CAS No.: 76702-30-2
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4-Mercaptobutanoic acid
0 ImagesCat. No.: HY-W612202CAS No.: 13095-73-3
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Tert-butyl (7-bromoheptyl)(methyl)carbamate
0 ImagesCat. No.: HY-W941702CAS No.: 2734864-63-0
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Methyl (1S,2R)-2-(2-hydroxyethyl)cyclopropane-1-carboxylate
0 ImagesCat. No.: HY-W108822CAS No.: 2165933-01-5
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1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid
![1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w168255.gif "Click to View 1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W168255CAS No.: 889952-23-2
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4-(4-Methoxyphenyl)-1-butanol
0 ImagesCat. No.: HY-W007982CAS No.: 52244-70-9
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Boc-NH-C5-NH-Me
0 ImagesCat. No.: HY-W396031CAS No.: 1311458-36-2
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4-(2-Aminoethoxy)benzoic acid hydrochloride
0 ImagesCat. No.: HY-W249270CAS No.: 1050208-10-0
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5-Ethynyl-2'-deoxyuridine (Standard)
0 ImagesCat. No.: HY-118411RCAS No.: 61135-33-9Synonyms: EdU (Standard)5-Ethynyl-2'-deoxyuridine (Standard) is the analytical standard of 5-Ethynyl-2'-deoxyuridine (HY-118411). This product is intended for research and analytical applications. 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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3,3'-Piperazine-1,4-diyldipropanoic acid
0 ImagesCat. No.: HY-W460315CAS No.: 5649-49-0
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Methyl 2-(4-(hydroxymethyl)phenyl)acetate
0 ImagesCat. No.: HY-W129322CAS No.: 155380-11-3
![(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate](https://file.medchemexpress.com/product_pic/hy-w711915.gif "Click to View (6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate Product Detail")
