Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Parasite Produits associés (2481)
Produits associés (2481)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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DL-threo-PPMP hydrochloride
0 ImagesDL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies.
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Rafoxanide-13C6
0 ImagesCat. No.: HY-17598SCAS No.: 1353867-98-7Rafoxanide 13C6 is a labeled Rafoxanide (HY-17598). Rafoxanide is a salicylanilide used as an antiparasitic agent.
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Antimalarial agent 10
0 ImagesCat. No.: HY-143409CAS No.: 2747280-03-9Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is.
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Rafoxanide (Standard)
0 ImagesRafoxanide (Standard) is the analytical standard of Rafoxanide. This product is intended for research and analytical applications. Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research.
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Piperonyl butoxide (Standard)
0 ImagesPiperonyl butoxide (Standard) is the analytical standard of Piperonyl butoxide. This product is intended for research and analytical applications. Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice.
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Secnidazole hemihydrate
0 ImagesCat. No.: HY-B1118ACAS No.: 227622-73-3Synonyms: RP-14539 hemihydrate; PM-185184 hemihydrateSecnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis.
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Niclosamide (GMP)
0 ImagesNiclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells.
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Ludaconitine
0 ImagesLudaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC50 of 36.10 μg/mL.
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Antimycobacterial agent-4
0 ImagesAntimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line.
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6-Dehydro-10-gingerol
0 ImagesCat. No.: HY-N15734CAS No.: 1345675-46-86-Dehydro-10-gingerol is an antiparasitic compound that can be isolated from ginger roots .
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Niclosamide-13C6 monohydrate
0 ImagesCat. No.: HY-B0497BSCAS No.: 1325559-12-3Synonyms: BAY2353-13C6 monohydrateNiclosamide-13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells.
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4-Hydroxy-2-methoxybenzamide
0 ImagesCat. No.: HY-N19238CAS No.: 84224-28-24-Hydroxy-2-methoxybenzamide is a phenolic amide natural product that can be isolated from the mangrove plant Aegiceras corniculatum. 4-Hydroxy-2-methoxybenzamide exhibits moderate antimalarial activity. It also serves as a chemical intermediate. 4-Hydroxy-2-methoxybenzamide can be used in malaria-related research.
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PAM 1392
0 ImagesCat. No.: HY-124112CAS No.: 13794-65-5PAM 1392 is active orally against Plasmodium berghei in mice, P. cynofologi and P. knowlesi in monkeys and Trypanosoma cruzi in tissue cultures of mice, and hemolytic streptococci in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria.
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1-(26-Hydroxyhexacosanoyl)-glycerol
0 ImagesCat. No.: HY-N3957CAS No.: 177602-14-11-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC50 value of 9.48 µM for Plasmodium falciparum.
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DHODH-IN-29
0 ImagesCat. No.: HY-175259CAS No.: 212375-00-3DHODH-IN-29 (Compound 2i) is a covalent inhibitor of Leishmania braziliensis Dihydroorotate Dehydrogenase (LbDHODH) with an IC50 value of 0.5 μM. DHODH-IN-29 is promising for research of antileishmaniasis.
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1-Deacetylnimbolinin B
0 ImagesCat. No.: HY-N1621CAS No.: 76689-98-01-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties.
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AcrB-IN-4
0 ImagesCat. No.: HY-149812CAS No.: 2890177-95-2Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.
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Dymanthine
0 ImagesDymanthine (N,N-Dimethyloctadecan-1-amine) is a broad-spectrum intestinal anthelmintic. Dymanthine is used in research related to various helminth infections (Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma duodenale).
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Antifungal agent 26
0 ImagesCat. No.: HY-146747CAS No.: 2769834-78-6Antifungal agent 26, a Pradimicin A derivative, shows antifungal, antiviral, and antiparasitic activities through binding to d-mannose (Man)-containing glycans of pathogenic species.
