Proteasome Ligand
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RAPRMT5
0 ImagesCat. No.: HY-181521CAS No.: 2721998-42-9
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Biotin-epoxomicin
0 ImagesCat. No.: HY-P11307CAS No.: 1334608-28-4Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma.
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RA183
0 ImagesCat. No.: HY-181523CAS No.: 2649154-64-1RA183 is a proteasome ligand that can be used to synthesize CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5 (HY-181521).
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RA183-CO-C6-NHCO-NH-Boc
0 ImagesCat. No.: HY-181524RA183-CO-C6-NHCO-NH-Boc is a proteasome ligand-linker conjugate that can be used for the synthesis of CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5 (HY-181521).
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RAFKBP12
0 ImagesCat. No.: HY-181498CAS No.: 2375455-59-5RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
