YAP/TAZ-TEAD Degrader

YAP/TAZ-TEAD Degrader (1):

Cat. No.	Product Name	Effect	Purity

HY-186021

PROTAC TEAD degrader-2	Degrader
PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC₅₀ of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC₅₀ of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma.

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