Endonuclease Inhibitor
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Cap-dependent endonuclease-IN-29
0 ImagesCat. No.: HY-171729CAS No.: 2408318-14-7Cap-dependent endonuclease-IN-29 is a Cap-dependent endonuclease inhibitor and a stereoselective synthetic intermediate. Cap-dependent endonuclease-IN-29 can be used in research on viral infections.
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MBXC-4522
0 ImagesCat. No.: HY-187464CAS No.: 1340680-75-2MBXC-4522 is an RVFV-EndoN inhibitor with an IC50 of 2.8 μM. MBXC-4522 exhibits antiviral activity. MBXC-4522 binds to and stabilizes the RVFV endonuclease through a metal-independent mechanism, inhibiting its activity and thereby blocking the viral "cap-snatching" mechanism. MBXC-4522 can be used for research on Rift Valley fever virus infection.
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PAN endonuclease-IN-3
0 ImagesCat. No.: HY-174431PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model.
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