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製品番号: HY-187464

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MBXC-4522

MBXC-4522 is an RVFV-EndoN inhibitor with an IC₅₀ of 2.8 μM. MBXC-4522 exhibits antiviral activity. MBXC-4522 binds to and stabilizes the RVFV endonuclease through a metal-independent mechanism, inhibiting its activity and thereby blocking the viral "cap-snatching" mechanism. MBXC-4522 can be used for research on Rift Valley fever virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1340680-75-2
分子式: C₂₃H₂₉N₅O₂S
分子量:439.57

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MBXC-4522 構造式

CAS 番号: 1340680-75-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	30.1 μM	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay. Cytotoxicity against human HEK293 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.	40787859
HepG2	CC₅₀	73.8 μM	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay. Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.	40787859
Vero	CC₅₀	45.0 μM	Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay. Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.	40787859
BV-2	CC₅₀	43.0 μM	Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay. Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.	40787859

体外実験

Viral InfectionOthers

Viral Infection

MBXC-4522 (5-50 μM; 16 h) significantly inhibits RVFV-MP12GFP attenuated virus infection in BV2 cells^[1].
MBXC-4522 inhibits purified RVFV-EndoN endonuclease activity in a dose-dependent manner, with an IC₅₀ of 2.8 μM^[1].
MBXC-4522 (5-50 μM; 18 h) inhibits RVFV (ZH501), SFTSV, and HRTV viral antigen expression, plaque formation, and reduces viral RNA levels in Vero E6 cells^[1].

Others

MBXC-4522 (0.1-100 μM; 72 h) exhibits dose-dependent cytotoxicity with low cytotoxicity in HEK293 (CC₅₀ = 30.1 µM), HepG2 (CC₅₀ = 73.8 µM), Vero (CC₅₀ = 45.0 µM), and BV2 (CC₅₀ = 43.0 µM) cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293, HepG2, Vero6, BV2
Concentration:

0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100 μM
Incubation Time:

72 h
Result:

Exhibited CC50 values of 30.1 μM in HEK293 cells, 73.8 μM in HepG2 cells, 45.0 μM in Vero6 cells, and 43.0 μM in BV2 cells.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 1340680-75-2
分子量 439.57
分子式 C₂₃H₂₉N₅O₂S
SMILES

O=S(C1=C(C)C=CC=C1)(N2CC3(NC4=CC=CN=C4N=C3NC5CCCC5)CCC2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kirby CD, et al. Identification and Characterization of a Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor. ACS infectious diseases. 2025 Sep 12;11(9):2373-2382.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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