2. Signaling Pathways
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Related Products (10876):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W654319
    Tri-p-tolyl phosphate-d21
    Tri-p-tolyl phosphate-d21 is the deuterium labeled Tri-p-tolyl phosphate.
    Tri-p-tolyl phosphate-d<sub>21</sub>
  • HY-13619S
    Efaproxiral-d6
    Efaproxiral (RSR13)-d6 is the deuterium labeled Efaproxiral (HY-13619). Efaproxiral is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .
    Efaproxiral-d<sub>6</sub>
  • HY-17492S3
    Zafirlukast-d6
    Zafirlukast-d6 is deuterated labeled Zafirlukast (HY-17492). Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
    Zafirlukast-d<sub>6</sub>
  • HY-W653853
    Ritonavir-13C3
    Ritonavir-13C3 is 13C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-<sup>13</sup>C<sub>3</sub>
  • HY-W744264
    Flumazenil-d5
    Flumazenil-d5 is deuterium labeled Flumazenil.
    Flumazenil-d<sub>5</sub>
  • HY-B1811S1
    Vasopressin-d5
    Vasopressin-d5 is anIsotope-labeled compound of Vasopressin. Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
    Vasopressin-d<sub>5</sub>
  • HY-P0119S
    Lixisenatide (Leu-13C6,15N) TFA
    Lixisenatide (Leu-13C6,15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis.
    Lixisenatide (Leu-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N) TFA
  • HY-N0095S
    (S)-10-Hydroxycamptothecin-d5
    (S)-10-Hydroxycamptothecin-d5 (10-HCPT-d5) is the deuterium labeled (S)-10-Hydroxycamptothecin. (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia research.
    (S)-10-Hydroxycamptothecin-d<sub>5</sub>
  • HY-W714702S
    2-((2,6-Dimethylphenyl)(2-(methoxy-d3)ethyl)amino)-2-oxoacetic acid
    2-((2,6-Dimethylphenyl)(2-(methoxy-d3)ethyl)amino)-2-oxoacetic acid is deuterium labeled 2-((2,6-Dimethylphenyl)(2-methoxyethyl)amino)-2-oxoacetic acid.
    2-((2,6-Dimethylphenyl)(2-(methoxy-d<sub>3</sub>)ethyl)amino)-2-oxoacetic acid
  • HY-B0696S1
    Tiagabine-d4
    Tiagabine-d4 (NO050328-d4) is deuterium labeled Tiagabine. Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease.
    Tiagabine-d<sub>4</sub>
  • HY-12769S2
    Mebeverine acid-d3
    Mebeverine acid-d3 (Mebeverine metabolite Mebeverine acid-d3) is the deuterium labeled Mebeverine Acid (HY-12769). Mebeverine acid is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid is an important marker for oral Mebeverine.
    Mebeverine acid-d<sub>3</sub>
  • HY-17368S1
    (Rac)-Rivastigmine-d6
    (Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    (Rac)-Rivastigmine-d<sub>6</sub>
  • HY-15746S1
    (rac)-Dobutamine-d6 hydrochloride
    (rac)-Dobutamine-d6 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
    (rac)-Dobutamine-d<sub>6</sub> hydrochloride
  • HY-N0221S2
    Daurisoline-d11
    Daurisoline-d11 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
    Daurisoline-d<sub>11</sub>
  • HY-132545S
    RPR132595A-d3
    RPR132595A-d3 is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of Irinotecan (CPT-11), which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
    RPR132595A-d<sub>3</sub>
  • HY-W007608S
    1-Iodonaphthalene-d7
    1-Iodonaphthalene-d7 is the deuterium labeled 1-Iodonaphthalene (HY-W007608).
    1-Iodonaphthalene-d<sub>7</sub>
  • HY-W748321
    2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl-13C12
    2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl-13C12 is 13C labeled 2,2',3,4',5,6,6'-Heptachloro-1,1'-biphenyl.
    2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl-<sup>13</sup>C<sub>12</sub>
  • HY-132383S
    24,25-Dihydroxy Vitamin D2-d3
    24,25-Dihydroxy Vitamin D2-d3 is the deuterium labeled 24,25-Dihydroxy Vitamin D2.
    24,25-Dihydroxy Vitamin D2-d<sub>3</sub>
  • HY-W012832S
    2-Ethyl-3-methylpyrazine-d3
    2-Ethyl-3-methylpyrazine-d3 is deuterated labeled 2-Ethyl-3-methylpyrazine.
    2-Ethyl-3-methylpyrazine-d<sub>3</sub>
  • HY-W716523
    Diethyl adipate-d10
    Diethyl adipate-d10 is the deuterium labeled Diethyl adipate.
    Diethyl adipate-d<sub>10</sub>