mGluR
Metabotropic glutamate receptors
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.
mGluR Isoform Specific Products
All Product Categories
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mGluR Related Products (399)
Related Products (399)
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Antibodies (8)
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mGluR Isoform Comparison
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VU0092273
0 ImagesVU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM.
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(S)-HexylHIBO
0 ImagesCat. No.: HY-103560CAS No.: 334887-48-8(S)-HexylHIBO is the S-enantiomer of HexylHIBO. HexylHIBO is a group I mGluR antagonist. HexylHIBO elevates the hypothalamus-pituitary-adrenal axis response to restraint in rats. HexylHIBO is promising for research of central nervous system-related diseases.
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THIIC
0 ImagesCat. No.: HY-116236CAS No.: 1204737-09-6Synonyms: LY2607540THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.
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MPPG TFA
0 ImagesCat. No.: HY-101241BPurity: 99.68%MPPG TFA, phenylglycine analogue, is a potent and selective metabotropic glutamate receptor (mGluR) antagonist with a kD value of 9.2 μM. MPPG TFA antagonizes both L-AP4 (HY-100781A)- and (1 S,3S)-ACPD-induced depressions of the monosynaptic excitation.
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Fenobam hydrate
0 ImagesCat. No.: HY-101478ACAS No.: 63540-28-3Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction.
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mGlu4 receptor agonist 1
0 ImagesCat. No.: HY-144698CAS No.: 1678501-16-0mGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC50 of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect.
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VU6031545
0 ImagesCat. No.: HY-176420CAS No.: 3107596-27-7VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats.
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Lu AF11205
0 ImagesCat. No.: HY-117697CAS No.: 1290133-16-2Lu AF11205 is a mGlu5 receptor positive allosteric modulator with activity modulating mGlu5 receptor activity. Optimization of Lu AF11205 resulted in a series of potent fused thiazole analogs whose structures and activities were influenced by substituents and which could affect receptor function in cell lines expressing mGlu5 receptors.
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LY2979165 free base
0 ImagesCat. No.: HY-13239ACAS No.: 1311385-35-9LY2979165 free base is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.
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VU0404251
0 ImagesCat. No.: HY-116067CAS No.: 1276013-77-4VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis.
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MGS0028
0 ImagesCat. No.: HY-131287CAS No.: 321963-33-1MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research.
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MFZ 10-7 hydrochloride
0 ImagesCat. No.: HY-103575ACAS No.: 1779796-36-9MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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VU6053371
0 ImagesCat. No.: HY-184475Synonyms: BI03738809VU6053371 (BI03738809) is a first-in-class (FIC), selective, orally active, and brain-penetrant metabotropic glutamate receptor subtype 3 (mGlu3) positive allosteric modulator (PAM) with EC50s of 103 nM and 112 nM for human and rat mGlu3. VU6053371 exhibits selectivity for mGlu3 over other mGlu receptor subtypes. VU6053371 exhibits pro-cognitive effects in mouse models. VU6053371 can be used in research schizophrenia, Alzheimer’ s disease and other forms of dementia and cognitive impairment.
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AZ12559322
0 ImagesCat. No.: HY-163831CAS No.: 947184-66-9AZ12559322 is a positive allosteric modulator of mGluR2, with the Ki value of 1.31 nM. AZ12559322 can be used in neurological research.
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TC-N 22A
0 ImagesCat. No.: HY-18679CAS No.: 1314140-00-5TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.
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Ro 64-5229
0 ImagesCat. No.: HY-103557CAS No.: 246852-46-0Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.
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MTPG
0 ImagesCat. No.: HY-101247CAS No.: 169209-66-9
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Z-Cyclopentyl-AP4
0 ImagesCat. No.: HY-103549CAS No.: 103439-17-4Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (orthosteric agonist). Z-Cyclopentyl-AP4 is more selective for mGlu4 than mGlu8.
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BAY 36-7620
0 ImagesCat. No.: HY-107513CAS No.: 232605-26-4BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research.
