1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. MFZ 10-7 hydrochloride

MFZ 10-7 hydrochloride 

Cat. No.: HY-103575A
Handling Instructions

MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats.

For research use only. We do not sell to patients.

MFZ 10-7 hydrochloride Chemical Structure

MFZ 10-7 hydrochloride Chemical Structure

CAS No. : 1779796-36-9

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Description

MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats[1].

IC50 & Target[1]

rat mGluR5

0.67 nM (Ki)

In Vitro

MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].

In Vivo

MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats[1].
MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1].

Animal Model: Male Long-Evans rats (250-300 g)[1]
Dosage: 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection, single injection
Result: Dose-dependently shifted the cocaine dose-response curve downward and inhibited cocaine self-administration maintained by a high dose (0.5 mg/kg/infusion) of cocaine.
Molecular Weight

272.70

Formula

C₁₅H₁₀ClFN₂

CAS No.

1779796-36-9

SMILES

N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MFZ 10-7mGluRMetabotropic glutamate receptorsmGluR5NAMantagonistcocaineself-administrationcocaine-takingcocaine-seekingInhibitorinhibitorinhibit

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MFZ 10-7 hydrochloride
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HY-103575A
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