2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. MFZ 10-7

MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

MFZ 10-7 Chemical Structure

MFZ 10-7 Chemical Structure

CAS No. : 1224431-15-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 185 In-stock
Solution
10 mM * 1 mL in DMSO USD 185 In-stock
Solid
1 mg USD 71 In-stock
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 850 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

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MFZ 10-7 Related Antibodies

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Description

MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

rat mGluR5

0.67 nM (Ki)

In Vitro

MFZ 10-7 has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MFZ 10-7 Related Antibodies
In Vivo

MFZ 10-7 can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

236.24

Formula

C15H9FN2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.86 mg/mL (75.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2330 mL 21.1649 mL 42.3298 mL
5 mM 0.8466 mL 4.2330 mL 8.4660 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2330 mL 21.1649 mL 42.3298 mL 105.8246 mL
5 mM 0.8466 mL 4.2330 mL 8.4660 mL 21.1649 mL
10 mM 0.4233 mL 2.1165 mL 4.2330 mL 10.5825 mL
15 mM 0.2822 mL 1.4110 mL 2.8220 mL 7.0550 mL
20 mM 0.2116 mL 1.0582 mL 2.1165 mL 5.2912 mL
25 mM 0.1693 mL 0.8466 mL 1.6932 mL 4.2330 mL
30 mM 0.1411 mL 0.7055 mL 1.4110 mL 3.5275 mL
40 mM 0.1058 mL 0.5291 mL 1.0582 mL 2.6456 mL
50 mM 0.0847 mL 0.4233 mL 0.8466 mL 2.1165 mL
60 mM 0.0705 mL 0.3527 mL 0.7055 mL 1.7637 mL
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MFZ 10-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MFZ 10-71224431-15-5mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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