MFZ 10-7
Based on 1 Customer Validation
MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 1224431-15-5
- Formula: C15H9FN2
- Molecular Weight:236.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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GPCR/G Protein Compound Library
HY-L006
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Neuronal Signaling Compound Library
HY-L013
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Neurotransmitter Receptor Compound Library
HY-L062
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Antidepressant Compound Library
HY-L108
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Heterocyclic Compound Library
HY-L138
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Allosteric Modulators (AMs) Compound Library
HY-L170
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
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Alkyne Compound Library
HY-L258
Biological Activity
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rat mGluR5 0.67 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.22 nM
Compound: 2d
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Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization
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[PMID: 21546249] |
| HEK293-A | IC50 |
2.4 nM
Compound: 7i, MFZ 10-7
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Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 production by ELISA
Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 production by ELISA
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[PMID: 22924094] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1224431-15-5
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Appearance Solid
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Molecular Weight 236.24
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Formula C15H9FN2
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Color Light yellow to yellow
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SMILES
N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 17.86 mg/mL (75.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2330 mL | 21.1649 mL | 42.3298 mL | 105.8246 mL |
| 5 mM | 0.8466 mL | 4.2330 mL | 8.4660 mL | 21.1649 mL | |
| 10 mM | 0.4233 mL | 2.1165 mL | 4.2330 mL | 10.5825 mL | |
| 15 mM | 0.2822 mL | 1.4110 mL | 2.8220 mL | 7.0550 mL | |
| 20 mM | 0.2116 mL | 1.0582 mL | 2.1165 mL | 5.2912 mL | |
| 25 mM | 0.1693 mL | 0.8466 mL | 1.6932 mL | 4.2330 mL | |
| 30 mM | 0.1411 mL | 0.7055 mL | 1.4110 mL | 3.5275 mL | |
| 40 mM | 0.1058 mL | 0.5291 mL | 1.0582 mL | 2.6456 mL | |
| 50 mM | 0.0847 mL | 0.4233 mL | 0.8466 mL | 2.1165 mL | |
| 60 mM | 0.0705 mL | 0.3527 mL | 0.7055 mL | 1.7637 mL |
MFZ 10-7 Related Classifications
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