334887-48-8
334887-48-8
Chemical Structure
(S)-HexylHIBO
- CAS No.: 334887-48-8
- Formula:C12H20N2O4
- Molecular Weight:256.30
IUPAC Name: (S)-2-amino-3-(4-hexyl-3-oxo-2,3-dihydroisoxazol-5-yl)propanoic acid
InChIKey: OKJBLHIYOWSQDJ-VIFPVBQESA-N
SMILES: O=C(O)[C@@H](N)CC(ON1)=C(CCCCCC)C1=O
Biological Activity: (S)-HexylHIBO is the S-enantiomer of HexylHIBO. HexylHIBO is a group I mGluR antagonist. HexylHIBO elevates the hypothalamus-pituitary-adrenal axis response to restraint in rats. HexylHIBO is promising for research of central nervous system-related diseases[1][2].
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(S)-HexylHIBO | (S)-HexylHIBO is the S-enantiomer of HexylHIBO. HexylHIBO is a group I mGluR antagonist. HexylHIBO elevates the hypothalamus-pituitary-adrenal axis response to restraint in rats. HexylHIBO is promising for research of central nervous system-related diseases. | |||||||||||||||||||||
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References
- [1]. Evanson NK, et al. Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stress. Physiol Behav. 2015 Oct 15;150:2-7. [Content Brief]
- [2]. Madsen U, et al. 4-Alkylated homoibotenic acid (HIBO) analogues: versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes. Neuropharmacology. 2005;49 Suppl 1:114-9. [Content Brief]
Keywords
