2. Signaling Pathways
  3. Anti-infection
  4. TMV

TMV

Tobacco mosaic virus

Tobacco mosaic virus (TMV) is named for one of the first plants in which it was found in the 1886. TMV can infect well over 350 different species of plants, many of which are favorites in home gardens such as tomatoes and potatoes. However TMV exclusively infects plants and is completely harmless for mammals. The rod-shaped virus particles (virions) of TMV measure about 300 nm x 15 nm. A single TMV particle is composed of 2,130 copies of the coat protein (CP) that envelope the RNA molecule of about 6,400 nucleotides. This single-stranded RNA encodes four genes: two replicase-associated proteins that are directly translated from the TMV RNA, and the movement protein and a coat protein that are translated from subgenomic RNAs. TMV is the textbook example for self-assembly. The assembly of the CPs (with or without RNA) to viruslike tubes is becoming an attractive way for nanoscale construction.

TMV Related Products (37):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-152259
    TMV-IN-4
    		Inhibitor
    TMV-IN-4 (compound 3) is a tobacco mosaic virus (TMV) inhibitor that effectively induces resistance and enhances plant tolerance to TMV infection by interacting with TMV helicase. TMV-IN-4 enhances peroxidase and superoxide dismutase activity, thereby increasing resistance to TMV in tobacco.
    TMV-IN-4
  • HY-N1836
    3-Acetonyl-3-hydroxyoxindole
    		Inhibitor
    3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity.
    3-Acetonyl-3-hydroxyoxindole
  • HY-163201
    TMV-IN-7
    		Inhibitor
    TMV-IN-7 (compound G2) is a potent inhibitor of tobacco mosaic virus (TMV). TMV-IN-7 exhibits strong hydrophobic interactions to obstructing the virus’s self-assembly.
    TMV-IN-7
  • HY-N8521
    6-O-Methacrylate
    6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC50 of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity.
    6-O-Methacrylate
  • HY-162400
    TMV-IN-8
    		Inhibitor
    TMV-IN-8 (compound 7 d) is an anti tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL.TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppressed TMV coat protein gene expression and biosynthesis process.
    TMV-IN-8
  • HY-P10562
    BMV Gag-(7−25)
    BMV Gag-(7 25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7 25) can be used in drug delivery and gene therapy research.
    BMV Gag-(7−25)
  • HY-N7194
    Yadanzioside L
    Yadanzioside L is a quassinoid and shows anti-tobacco mosaic virus (TMV) activity (IC50=4.86 μM).
    Yadanzioside L
  • HY-148567
    TMV-IN-1
    		Inhibitor
    TMV-IN-1, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-1 has good therapeutic activity and protective activity against TMV with EC50 values of 70.7 μg/mL and 60.8 μg/mL, respectively. TMV-IN-1 can be used for the research of infection, inflammation and tumor.
    TMV-IN-1
  • HY-119458
    Luotonin A
    		Inhibitor
    Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.
    Luotonin A
  • HY-W718796
    DL-Serine-15N
    DL-Serine-15N is 15N-labeled DL-Serine (HY-Y0507) DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
    DL-Serine-<sup>15</sup>N
  • HY-161955
    TMV-IN-11
    		Inhibitor
    TMV-IN-11 (compound syn-3g) is a potent TMV inhibitor with high inactivation capacity (IC50: 120.7 μg/mL). TMV-IN-11 can effectively inhibit the expression of TMV.
    TMV-IN-11
  • HY-169186
    TMV-IN-13
    		Inhibitor
    TMV-IN-13 (compund 5g) has anti-TMV activity.
    TMV-IN-13
  • HY-179569
    Antiviral agent 73
    		Inducer
    Antiviral agent 73 (compound D13) is a potent intercellular movement inhibitor with antiviral activity. Antiviral agent 73 shows inactivation activity against potato virus Y (PVY) with an EC50 of 79.5 μg/mL. Antiviral agent 73 effectively inhibits virus infection by forming stable hydrogen bonds with Pro154 of PVY coat protein. Antiviral agent 73 can interfere with the process of Pro154-mediated viral intercellular trafficking in plasmodesmata. Antiviral agent 73 can be used for plant virus prevention and control.
    Antiviral agent 73
  • HY-163754
    TMV-IN-9
    		Inhibitor
    TMV-IN-9 (compound A6) is an antiviral agent that displays excellent inactivating against tobacco mosaic virus (TMV) with an EC50 of 62.8 μg/mL. TMV-IN-9 shows strong binding capacity to TMV coat protein with a binding affinity value of 1.862 μM. TMV-IN-9 obviously destroys the integrity of the TMV particles and blocked the virus from infecting the host.
    TMV-IN-9
  • HY-163999
    TMV-IN-12
    		Inhibitor
    TMV-IN-12 (compound 4) is an inhibitor of tobacco mosaic virus (TMV) with antifungal properties. TMV-IN-12 effectively prevents TMV particle aggregation and self-assembly of TMV capsid protein (TMV-CP) (Kd=0.142 μM), preventing TMV from infecting tobacco plants.
    TMV-IN-12
  • HY-180272
    TMV-IN-15
    		Inhibitor
    MV-IN-15 (compound 4AF) is a potent antiviral and antifungal agent. TMV-IN-15 suppresses viral particle assembly by binding to the TMV-CP, inducing prominent aggregation and structural fusion. TMV-IN-15 exhibits inhibitory activity against Physalospora piricola and Rhizoctonia cereal. TMV-IN-15 can be used for pesticides research.
    TMV-IN-15
  • HY-N13047
    Ningnanmycin
    		Inhibitor
    Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection.
    Ningnanmycin