TMV Inhibitor

trans-3-(3-Pyridyl) acrylic acid is an unsaturated carboxylic acid and synthetic building block, which serves as a synthetic precursor of 3-(3-pyridyl) propanoic acid. trans-3-(3-Pyridyl) acrylic acid can be used to prepare dual mutant IDH1/NAMPT inhibitors and PGE₂ antagonist analogs. In addition, trans-3-(3-Pyridyl) acrylic acid exhibits antiviral activity against tobacco mosaic virus (TMV).

Meliatoosenin N is a limonoid compound. Meliatoosenin N inhibits the replication of tobacco mosaic virus in vitro.

Hylonoside I is a TMV inhibitor that inhibits the proliferation of TMV. Hylonoside I can be isolated from the leaves of Ilex hylonoma. Hylonoside I is applicable to the research of TMV infection.

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC₅₀=97.9 μM) and inhibits cancer cell proliferation (EC₅₀ of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC₅₀=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC₅₀=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

TMV-IN-3, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-3 has antiviral activity against TMV with an EC₅₀ value of 120.3 μg/mL. TMV-IN-3 can be used for the research of infection, inflammation and tumor.

TMV-IN-2, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-2 has antiviral activity against TMV with an EC₅₀ value of 89.9 μg/mL. TMV-IN-2 can be used for the research of infection, inflammation and tumor.

TMV-IN-10 (compound 4h) is an arecoline derivative with anti-tobacco mosaic virus (TMV) activity (EC₅₀=146 µg/mL). TMV-IN-10 can be used in research on controlling crop pests and diseases and improving crop yields by acting on the viral coat protein (CP) to cause viral fragmentation.

TMV-IN-6 (Compound 4g) is a novel antiviral and fungicidal agent. TMV-IN-6 inhibits virus assembly by binding totobacco mosaic virus (TMV) CP and interfere with the assembly process of TMV CP and RNA.

TMV-IN-14 (compound A21) is an agrochemical agent withstrongly interaction between with TMV coat protein through various interactions.

TMV-IN-4 (compound 3) is a tobacco mosaic virus (TMV) inhibitor that effectively induces resistance and enhances plant tolerance to TMV infection by interacting with TMV helicase. TMV-IN-4 enhances peroxidase and superoxide dismutase activity, thereby increasing resistance to TMV in tobacco.

3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity.

TMV-IN-7 (compound G2) is a potent inhibitor of tobacco mosaic virus (TMV). TMV-IN-7 exhibits strong hydrophobic interactions to obstructing the virus’s self-assembly.

TMV-IN-8 (compound 7 d) is an anti tobacco mosaic virus (TMV) agent with an antiviral EC₅₀ of 157.6 μg/mL.TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppressed TMV coat protein gene expression and biosynthesis process.

TMV-IN-1, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-1 has good therapeutic activity and protective activity against TMV with EC₅₀ values of 70.7 μg/mL and 60.8 μg/mL, respectively. TMV-IN-1 can be used for the research of infection, inflammation and tumor.

Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.

TMV-IN-11 (compound syn-3g) is a potent TMV inhibitor with high inactivation capacity (IC₅₀: 120.7 μg/mL). TMV-IN-11 can effectively inhibit the expression of TMV.

TMV-IN-13 (compund 5g) has anti-TMV activity.

TMV-IN-9 (compound A6) is an antiviral agent that displays excellent inactivating against tobacco mosaic virus (TMV) with an EC₅₀ of 62.8 μg/mL. TMV-IN-9 shows strong binding capacity to TMV coat protein with a binding affinity value of 1.862 μM. TMV-IN-9 obviously destroys the integrity of the TMV particles and blocked the virus from infecting the host.

TMV-IN-12 (compound 4) is an inhibitor of tobacco mosaic virus (TMV) with antifungal properties. TMV-IN-12 effectively prevents TMV particle aggregation and self-assembly of TMV capsid protein (TMV-CP) (Kd=0.142 μM), preventing TMV from infecting tobacco plants.

MV-IN-15 (compound 4AF) is a potent antiviral and antifungal agent. TMV-IN-15 suppresses viral particle assembly by binding to the TMV-CP, inducing prominent aggregation and structural fusion. TMV-IN-15 exhibits inhibitory activity against Physalospora piricola and Rhizoctonia cereal. TMV-IN-15 can be used for pesticides research.