95258-14-3
Chemical Structure
Yadanziolide A
- CAS No.: 95258-14-3
- Formula:C20H26O10
- Molecular Weight:426.41
IUPAC Name: (1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3-(hydroxymethyl)-8,11a-dimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione
InChIKey: QXKKRGMRXXMDDP-JVDXBALSSA-N
SMILES: O[C@@]1([C@H]2O)[C@@]34[C@@]([C@@H](O)[C@H](O)[C@]1(OC4)CO)([H])[C@]([C@@](C(C)=CC5=O)([H])C[C@@]3([H])OC2=O)([C@@H]5O)C
Biological Activity: Yadanziolide A is an antiviral, antimalarial, and anticancer agent. Yadanziolide A can be isolated from Brucea javanica. Yadanziolide A inhibits STAT3 phosphorylation/activation and JAK2 phosphorylation, induces Apoptosis, and reduces TNF-alpha levels. Yadanziolide A exhibits antiplasmodial activity against Chloroquine (HY-17589A)-resistant Plasmodium falciparum. Yadanziolide A has nematocidal activity against Dipogasteridae larvae. Yadanziolide A has anti-TMV and anti-HIV-1 activities. Yadanziolide A can be used for research on hepatocellular carcinoma and type 2 diabetes[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Yadanziolide A | 99.85% | Yadanziolide A is an antiviral, antimalarial, and anticancer agent. Yadanziolide A can be isolated from Brucea javanica. Yadanziolide A inhibits STAT3 phosphorylation/activation and JAK2 phosphorylation, induces Apoptosis, and reduces TNF-alpha levels. Yadanziolide A exhibits antiplasmodial activity against Chloroquine (HY-17589A)-resistant Plasmodium falciparum. Yadanziolide A has nematocidal activity against Dipogasteridae larvae. Yadanziolide A has anti-TMV and anti-HIV-1 activities. Yadanziolide A can be used for research on hepatocellular carcinoma and type 2 diabetes. | ||||||||||||||||||||
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Similarity Score 0.86
HY-N3014Bruceine D -
Similarity Score 0.86
HY-N7338Yadanziolide C -
Similarity Score 0.81
HY-N8399Yadanziolide B -
Similarity Score 0.76
HY-N9325Pasakbumin D -
Similarity Score 0.73
HY-N3015Bruceine E -
Similarity Score 0.72
HY-N932013,21-Dihydroeurycomanone -
Similarity Score 0.71
HY-N4328Pasakbumin B -
Similarity Score 0.69
HY-N432614,15 β-Dihydroxyklaineanone -
Similarity Score 0.67
HY-N5012REurycomanone (Standard) -
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References
- [1]. Yan XH, et al. Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. Journal of agricultural and food chemistry. 2010 Feb 10;58(3):1572-7. [Content Brief]
- [2]. Bawn S. Studies on antitrypanosomal activity of medicinal plants (Doctoral dissertation, et al.
- [3]. Lin L, et al. Yadanziolide a inhibits proliferation and induces apoptosis of hepatocellular carcinoma via JAK-STAT pathway: a preclinical study. Biology. 2024 Jul 16;13(7):528.
- [4]. O'Neill MJ, et al. Plants as sources of antimalarial drugs, Part 4: Activity of Brucea javanica fruits against chloroquine-resistant Plasmodium falciparum in vitro and against Plasmodium berghei in vivo. Journal of Natural Products. 1987 Jan;50(1):41-8.
- [5]. Lian Y, et al. Discovery of ten anti-HIV hit compounds and preliminary pharmacological mechanisms studies. Current HIV Research. 2024 Mar 1;22(2):82-90.
- [6]. Arwansyah A, et al. Binding patterns and structural dynamics of Brucea javanica bioactives as anti-diabetic leads: integrative insights from network-based analysis, fragment molecular orbital, and molecular dynamics simulations. Molecular Simulation. 2025 Dec 12;51(18):1184-204.
- [7]. Anderson MM. Cytotoxic and antimalarial natural products. University of London, et al.
- [8]. Watanabe I, et al. Nematocidal activity of quassinoids against a species of Diplogastridae. Biological & pharmaceutical bulletin. 2000 Jun;23(6):723-6.
