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Cat. No.: HY-182363

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A6CDQ

A6CDQ is a human organic cation transporter (hOCT) inhibitor with antidepressant-like activity that can cross the blood-brain barrier. A6CDQ potently inhibits the transport activities mediated by hOCT1, hOCT2 and hOCT3. A6CDQ exhibits significant antidepressant-like effects in the mouse tail suspension test. A6CDQ can be used in studies related to depression.

For research use only. We do not sell to patients.

CAS No.: 1005550-46-8
Formula: C₈H₈ClN₃
Molecular Weight:181.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

A6CDQ Chemical Structure

CAS No.: 1005550-46-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
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Biological Activity

Description

In Vitro

A6CDQ (10^-8-10^-3 M; 1 min) inhibits hOCT1, hOCT2, and hOCT3-mediated MPP⁺ transport in stably transfected HEK293 cells, with IC₅₀ values of 3.0 μM (hOCT1), 16.4 μM (hOCT2), and 3.9 μM (hOCT3)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A6CDQ (0.1-30 mg/kg; i.p.; single dose) exhibits antidepressant-like activity in the mouse tail suspension test with an ED₅₀ of 0.23 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice with Depression (male, 20−24 g)^[1]
Dosage:

0.1 mg/kg; 0.3 mg/kg; 1.0 mg/kg; 3.0 mg/kg; 10 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Significantly reduced immobility time compared to saline at 1.0 mg/kg.
Reached an ED50 of 0.23 mg/kg.

Chemical Information

CAS No. 1005550-46-8
Molecular Weight 181.62
Formula C₈H₈ClN₃
SMILES

NC1=NC2=C(CN1)C=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Iyer KA, et al. The 2-Amino-3,4-dihydroquinazoline Molecular Scaffold as Novel OCT3 Inhibitor. ACS Chem Neurosci. 2026;17(7):1375-1386. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
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A6CDQ

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A6CDQ Related Classifications

HY-182363 Related Classifications