2. Neuronal Signaling
  3. Serotonin Transporter
  4. A6CDQ

A6CDQ is a human organic cation transporter (hOCT) inhibitor with antidepressant-like activity that can cross the blood-brain barrier. A6CDQ potently inhibits the transport activities mediated by hOCT1, hOCT2 and hOCT3. A6CDQ exhibits significant antidepressant-like effects in the mouse tail suspension test. A6CDQ can be used in studies related to depression.

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A6CDQ

A6CDQ Chemical Structure

CAS No. : 1005550-46-8

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A6CDQ Related Antibodies

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Description

A6CDQ is a human organic cation transporter (hOCT) inhibitor with antidepressant-like activity that can cross the blood-brain barrier. A6CDQ potently inhibits the transport activities mediated by hOCT1, hOCT2 and hOCT3. A6CDQ exhibits significant antidepressant-like effects in the mouse tail suspension test. A6CDQ can be used in studies related to depression[1].

In Vitro

A6CDQ (10-8-10-3 M; 1 min) inhibits hOCT1, hOCT2, and hOCT3-mediated MPP+ transport in stably transfected HEK293 cells, with IC50 values of 3.0 μM (hOCT1), 16.4 μM (hOCT2), and 3.9 μM (hOCT3)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A6CDQ Related Antibodies
In Vivo

A6CDQ (0.1-30 mg/kg; i.p.; single dose) exhibits antidepressant-like activity in the mouse tail suspension test with an ED50 of 0.23 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice with Depression (male, 20−24 g)[1]
Dosage: 0.1 mg/kg; 0.3 mg/kg; 1.0 mg/kg; 3.0 mg/kg; 10 mg/kg; 30 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced immobility time compared to saline at 1.0 mg/kg.
Reached an ED50 of 0.23 mg/kg.
Molecular Weight

181.62

Formula

C8H8ClN3
CAS No.
SMILES

NC1=NC2=C(CN1)C=C(Cl)C=C2
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A6CDQ Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A6CDQ1005550-46-8Serotonin Transporter5-HTTSERTSLC6A4CYS477hOCT1human organic cation transporterdepressionSER474hOCT3mouse tail suspension testhOCT2ASP478HEK293 cellsInhibitorinhibitorinhibit

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