2. Apoptosis
  3. IAP
  4. AEG40826

AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an inhibitor of apoptosis (IAP) inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research.

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AEG40826

AEG40826 Chemische Struktur

CAS. Nr. : 949963-04-6

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AEG40826 Related Antibodies

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Alle IAP Isoform-spezifische Produkte anzeigen:

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cIAP cIAP-1 cIAP-2 XIAP

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Beschreibung

AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an inhibitor of apoptosis (IAP) inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research[1].

Klinische Studie
Molekulargewicht

1045.32

Formel

C58H80N10O8
CAS. Nr.
SMILES

CN[C@@H](C)C(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)NC(C2=CC=C(C=C2)C(N[C@@H]3CN([C@@H](C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)=O)=O)C(N[C@H]6C7=CC=CC=C7CCC6)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
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AEG40826 Related Classifications

  • Molaritätsrechner

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AEG40826949963-04-6HGS1029AEG 40826AEG-40826HGS 1029HGS-1029IAPIAP InhibitorcIAP1TNF-αsecond mitochondria-derived activator of caspases (SMAC) mimeticInhibitorinhibitorinhibit

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