α-Glucosidase-IN-118 

α-Glucosidase-IN-118 is a non-competitive inhibitor of α-glucosidase with a IC₅₀ of 2.77 μM, and it shows no inhibitory activity against β-glucosidase. α-Glucosidase-IN-118 binds to the entrance of the α-glucosidase active site to block substrate release. α-Glucosidase-IN-118 can be used in the research of diabetes, obesity and lysosomal storage diseases^[1].

α-Glucosidase-IN-118 (compound 3bd) (0.125-100 μM; 10 min pre-incubation + 20 min reaction) potently inhibits α-glucosidase from Saccharomyces cerevisiae as an uncompetitive inhibitor, with an IC₅₀ of 2.77 μM and a K_i value of 9.28 μM^[1].
α-Glucosidase-IN-118 binds to a pocket near the active site of α-glucosidase from Halomonas sp. H11 via hydrogen bonding, π-π stacking, and halogen bonding interactions, blocking substrate release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

357.38

C₂₀H₂₀FNO₄

[H][C@]12C[C@@]3([C@H]([C@H]([C@H](CN3C4=CC=CC(C5=CC=C(C=C5CO2)F)=C41)O)O)O)[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang W, et al.. Synthesis of novel 5,6,6a,8-tetrahydro-1H-benzo[5,6]oxepino[2,3,4-de]quinoline fused iminosugars as uncompetitive inhibitors against α-glucosidase. Bioorganic & Medicinal Chemistry Letters. 2026;136:130587.