α-Glucosidase-IN-118
α-Glucosidase-IN-118 is a non-competitive inhibitor of α-glucosidase with a IC50 of 2.77 μM, and it shows no inhibitory activity against β-glucosidase. α-Glucosidase-IN-118 binds to the entrance of the α-glucosidase active site to block substrate release. α-Glucosidase-IN-118 can be used in the research of diabetes, obesity and lysosomal storage diseases.
For research use only. We do not sell to patients.
- Formula: C20H20FNO4
- Molecular Weight:357.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α‑glucosidase 2.77 μM (IC50) |
α-Glucosidase-IN-118 (compound 3bd) (0.125-100 μM; 10 min pre-incubation + 20 min reaction) potently inhibits α-glucosidase from Saccharomyces cerevisiae as an uncompetitive inhibitor, with an IC50 of 2.77 μM and a Ki value of 9.28 μM[1].
α-Glucosidase-IN-118 binds to a pocket near the active site of α-glucosidase from Halomonas sp. H11 via hydrogen bonding, π-π stacking, and halogen bonding interactions, blocking substrate release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 357.38
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Formula C20H20FNO4
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SMILES
[H][C@]12C[C@@]3([C@H]([C@H]([C@H](CN3C4=CC=CC(C5=CC=C(C=C5CO2)F)=C41)O)O)O)[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-118 Related Classifications
HY-184340 Related Classifications
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