AMPK-α1β1γ1 activator 1
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy.
For research use only. We do not sell to patients.
- CAS No.: 1943510-86-8
- Formula: C25H24ClNO9
- Molecular Weight:517.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All AMPK Isoforms
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Biological Activity
EC50: 38.1nM (AMPK-α1β1γ1)[1]
Chemical Information
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CAS No. 1943510-86-8
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Molecular Weight 517.91
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Formula C25H24ClNO9
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SMILES
OC([C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC(C2=CNC3=CC(Cl)=C(C4=CC=C(C5(CCC5)O)C=C4)C=C23)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ryder TF, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Aug 23;61(16):7273-7288. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMPK-α1β1γ1 activator 1 Related Classifications
HY-157129 Related Classifications
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