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  4. Raleukin

Raleukin  (Synonyms: Kineret; Anakinra)

製品番号: HY-108841 純度: 99.40%
COA Technical Support

Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

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CAS 番号 : 143090-92-0

容量 価格（税別） 在庫状況 数量
1 mg $140 在庫あり
5 mg $350 在庫あり
10 mg $550 在庫あり
25 mg $1100 在庫あり
50 mg $1650 在庫あり
100 mg $2480 在庫あり
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500 mg   お問い合わせ  

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カスタマーレビュー

Based on 52 publication(s) in Google Scholar

Raleukin Featured Recommendations:

Raleukin 関連抗体

Top Publications Citing Use of Products

顧客検証

IF
Flow Cytometry
RT-PCR
In Vivo Imaging

    Raleukin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 24;10(1):417.  [Abstract]

    Bioluminescence imaging (BLI) on days 0, 5, and 10 posttreatment in BM-bearing mice. The treatment groups included vehicle, Raleukin (Anakinra) (100 mg/kg, intraperitoneally, daily), SH4-54 (10 mg/kg every 3 days), and anakinra + SH4-54.

    Raleukin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Jul 16.  [Abstract]

    Representative images and quantification of liver lesions in BALB/c mice intrasplenically injected with CT26 following AAV-SPHK1 or Anakinra (Raleukin) (500 µg; intraperitoneal injection on days 4, 7, 10, 13, and 16) treatment.

    Raleukin purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2025 Apr 7.  [Abstract]

    Ifnγ relative expression (n=3) in Th17 cells differentiated from CD4 Nlrp3-/- mice and their littermate (Lit) controls treated with CASPASE-1 inhibitor (ZYVAD), CASPASE-8 inhibitor (ZIETD), inflammasome inhibitor (MCC950), or Anakinra (Anak) (Raleukin) (300 nM).

    Raleukin purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2024 Mar;19(3):387-398.  [Abstract]

    Effect of IL-1 receptor blockage (IL-1RA, Raleukin) (50 mg/kg, daily) on the lineage shifts of haematopoietic progenitor cells due to administration of OMVs: schematic illustration of the experimental schedule and grouping information (c); frequency of LSKs in Lin-cells, ST-HSCs and MPPs in LSKs as determined by flow cytometry.

    Raleukin purchased from MedChemExpress. Usage Cited in: Circulation. 2021 Sep 14;144(11):893-908.  [Abstract]

    Adhesion of DiI-labeled peripheral blood mononuclear cells (PBMCs) stimulated with TNF-α (18 hours), LPS (18 hours), LPS plus OA (18 hours for LPS priming, 4 hours), or LPS plus oxalate (18 hours for LPS priming, 4 hours) to human aortic endothelial cells (HAECs) as determined by fluorescence microscopy (n=3 per group) in the presence of an anti-IL-1α blocking antibody (1 µg/mL) incubated with PBMCs or an anti-IL-1R1 blocking antibody (Raleukin, 500 ng/mL) incubated with HAECs (10 µg/mL) or an isotype control.

    Interleukin Related アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction[1][2][3].

    IC50 & Target

    IL-1

     

    体内実験

    Combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice[2].
    Raleukin (AMG-719) enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    17.3 kDa

    分子式

    C759H1186N208O232S10
    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Raleukin]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション

    純度: 99.40%

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Raleukin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Raleukin143090-92-0Kineret AnakinraInterleukin RelatedILrheumatoidarthritisInhibitorinhibitorinhibit

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    製品名:
    Raleukin
    製品番号:
    HY-108841
    数量:
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