2. Immunology/Inflammation
  3. NO Synthase
  4. Anti-inflammatory agent 19

Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.

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Anti-inflammatory agent 19

Anti-inflammatory agent 19 Estructura química

No. CAS : 2873386-63-9

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Anti-inflammatory agent 19 Related Antibodies

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Descripciòn

Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc[1].

IC50 & Target

IC50: 36.00 μM (NO)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
36 μM
Compound: 2b
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay
[PMID: 34800877]
Peso molecular

522.71

Fòrmula

C30H50O7
No. CAS
SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@@](C)([C@H]([C@H]4O)O)CO)C)C)([H])[C@](C)([C@](CC1)([H])[C@](C)(O)CO)CCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Referencias
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Anti-inflammatory agent 19 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 192873386-63-9NO SynthaseNitric oxide synthasesNOSRAW 264.7 cellsPentacyclic triterpenesPTsBiotransformationHigh mobility group box-1 proteinHMGB1Anti-inflammatory activityStreptomyces olivaceus CICC 236283,4-seco-triterpenesCOVID-19sepsisInhibitorinhibitorinhibit

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Nombre del producto:
Anti-inflammatory agent 19
Cat. No.:
HY-143457
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