Anti-inflammatory agent 19

Cat. No.: HY-143457: Fiche technique Instruction de manipulation
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Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC₅₀ of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.

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Anti-inflammatory agent 19 Chemical Structure

CAS No. : 2873386-63-9

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform NO Synthase:

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nNOS iNOS eNOS

Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target

IC₅₀: 36.00 μM (NO)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	36 μM Compound: 2b	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of HMGB1-induced NO production pretreated with compounds for 15 mins followed by HMGB1 stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 34800877]

Masse moléculaire

522.71

Formule

C₃₀H₅₀O₇

CAS No.

2873386-63-9

SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@@](C)([C@H]([C@H]4O)O)CO)C)C)([H])[C@](C)([C@](CC1)([H])[C@](C)(O)CO)CCC(O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhu Y, et al. Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628. Bioorg Med Chem. 2021 Dec 15;52:116494. [Content Brief]