Anti-inflammatory agent 51

Name: Anti-inflammatory agent 51
Brand: MedChemExpress
SKU: HY-155765
Rating: 4.5 (0 reviews)

Cat. No.: HY-155765 Pureza: 98.08%: Ficha de datos
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Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research.

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Anti-inflammatory agent 51 Estructura química

No. CAS : 2911610-03-0

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
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100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas NF-κB:

Ver todas las isoformas

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	0.61 μM Compound: 11d	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis	[PMID: 37572538]
J774.A1	IC₅₀	4.34 μM Compound: 11d	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis	[PMID: 37572538]

In Vitro

Anti-inflammatory agent 51 (compound 11d) potently reduces the release of IL-6 ( IC₅₀ value of 0.61 μM) and TNF-α (IC₅₀ of 4.34 μM) , and decreased the mRNA level of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 into the nucleus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-inflammatory agent 51 (compound 11d) improved LPS-induced acute lung injury (ALI) and alleviated DSS-induced ulcerative colitis in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

498.51

Fòrmula

C₂₂H₂₂N₆O₆S

No. CAS

2911610-03-0

Appearance

Solid

Color

Yellow to orange

SMILES

O=S(NCC1=CC=CC=N1)(C2=CC=C(C([N+]([O-])=O)=C2)N3CCN(CC3)C4=CC=C(C=C4)[N+]([O-])=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (250.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0060 mL	10.0299 mL	20.0598 mL
5 mM	0.4012 mL	2.0060 mL	4.0120 mL
10 mM	0.2006 mL	1.0030 mL	2.0060 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.08%

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Ficha de datos (271 KB) SDS (251 KB)

COA (248 KB) HNMR (282 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Pan Chen, et al. Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis. Eur J Med Chem. 2023 Aug 2;259:115706. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0060 mL	10.0299 mL	20.0598 mL	50.1494 mL
	5 mM	0.4012 mL	2.0060 mL	4.0120 mL	10.0299 mL
	10 mM	0.2006 mL	1.0030 mL	2.0060 mL	5.0149 mL
	15 mM	0.1337 mL	0.6687 mL	1.3373 mL	3.3433 mL
	20 mM	0.1003 mL	0.5015 mL	1.0030 mL	2.5075 mL
	25 mM	0.0802 mL	0.4012 mL	0.8024 mL	2.0060 mL
	30 mM	0.0669 mL	0.3343 mL	0.6687 mL	1.6716 mL
	40 mM	0.0501 mL	0.2507 mL	0.5015 mL	1.2537 mL
	50 mM	0.0401 mL	0.2006 mL	0.4012 mL	1.0030 mL
	60 mM	0.0334 mL	0.1672 mL	0.3343 mL	0.8358 mL
	80 mM	0.0251 mL	0.1254 mL	0.2507 mL	0.6269 mL
	100 mM	0.0201 mL	0.1003 mL	0.2006 mL	0.5015 mL