Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma^[1][2].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

CD122/IL-2Rβ

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg, i.p., every 3 days) restores tumor-specific CD8⁺ T cells activity and decreases tumor burden in hepatocellular carcinoma mice^[1].
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg/mouse, i.p., at days 7, 9, 12, 14 and 16) reduces CD8⁺CD122⁺ T cell population in B6 mice^[2].
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg/mouse, i.p., every 2-3 days for 5 times) suppresses tumor growth and prolongs survival companied with tumor vaccine in B16-OVA tumor mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16185  [NCBI]

P16297

in vitro NK cell negative selection; Immunoprecipitation; Flow cytometry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD122/IL-2Rβ Antibody (5H4)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lacotte S, et al. Anti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth. Oncoimmunology. 2023 Mar 2;12(1):2184991.  [Content Brief]

  [2]. Villarreal DO, et al. Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment. Oncotarget. 2017 Nov 24;8(65):109151-109160.  [Content Brief]