Antibacterial agent 127

Cat. No.: HY-151937: Data Sheet Handling Instructions
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Antibacterial agent 127 (Compound 23) is a potent antibacterial agent.

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Antibacterial agent 127 화학구조

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Antibacterial agent 127 (Compound 23) is a potent antibacterial agent^[1].

IC₅₀ & Target

Bacterial^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	> 100 μM Compound: 23	Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 36462445]

In Vitro

Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) shows antibacterial activity with MICs of 0.063, 0.063, 0.063, 0.25, 32 and 64 μg/mL against MSSA ATCC29213, MSSA ATCC25923, MRSAb, MRSEb, E.coli ATCC25922 and S.pullorum, respectively. And shows low cytotoxicity to RAW 264.7 cells (IC₅₀＞100 μM)^[1].
Antibacterial agent 127 shows good metabolic stability (t_1/2 = 3.25 min in rat liver microsomes)^[1].
Antibacterial agent 127 exhibits moderate inhibition effect on CYP3A4 (Midazolam) and CYP3A4 (Testosterone), with IC₅₀ values of 2.64 and 1.94 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 127 (Compound 23) (50 mg/kg; i.p.; single dose) inhibits MRSA effectively in a mouse thigh infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Kunming mice, neutropenic mouse thigh infection model^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, single dose
Result:	Reduced bacteria count with a value of 1.84 log₁₀ CFU/mL in comparison with vehicle control group.

분자량

527.68

화학식

C₂₈H₃₇N₃O₅S

SMILES

C[C@]([C@@H](O)[C@@H]1C)(C[C@@H](OC(CSC(N2)=NC3=C(C=CN3)C2=O)=O)[C@@]4(C)[C@@]5([H])[C@]1(CCC5=O)CC[C@H]4C)C=C

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Deng Y, et al. Antibacterial activity evaluation of pleuromutilin derivatives with 4(3H)-quinazolinone scaffold against methicillin-resistant Staphylococcusaureus. Eur J Med Chem. 2022 Nov 23;246:114960. [Content Brief]