AAAS Antibody (YA8749)
(Synonyms: AAA; AAASb; ADRACALA; ADRACALIN; ALADIN; GL003)AAAS Antibody (YA8749) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AAAS.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:150-500 |
Product Details
AAAS Antibody (YA8749) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AAAS.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 59.4 kDa
Human recombinant protein fragment corresponding to amino acids 322-546 of human AAAS produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AAAS plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment[1][2][3][4].
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Subcellular Localization
Nucleus, nuclear pore complex,Cytoplasm, cytoskeleton, spindle pole,Nucleus envelope
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Expression
Tissue_Specificity: Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947) -
Isoforms & Post-Translational Modification
Q9NRG9 has two isomers: Q9NRG9-1: 59574 Da (predicted); Q9NRG9-2: 55814 Da (predicted).
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Subunit
Interacts with NDC1, the interaction is required for nuclear pore localization (PubMed:19782045)
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SwissProt ID
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Synonyms
AAA; AAASb; ADRACALA; ADRACALIN; ALADIN; GL003
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