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ADAMTS4 Antibody (YA7743)(PBS only)

(Synonyms: ADAMTS-2; ADAMTS-4; ADMP-1)

ADAMTS4 Antibody (YA7743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAMTS4.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ADAMTS4 Antibody (YA7743)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-500

Product Details

Description

ADAMTS4 Antibody (YA7743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAMTS4.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Human recombinant protein fragment corresponding to amino acids 296-577 of human ADAMTS4 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ADAMTS4 cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease[1][2][3].

  • Subcellular Localization

    Secreted, extracellular space, extracellular matrix

  • Expression


    Tissue_Specificity: Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)
    Induction: By IL1/interleukin-1

  • Isoforms & Post-Translational Modification

    O75173 has two isomers: O75173-1: 90197 Da (predicted); O75173-2: 90065 Da (predicted).
    The precursor is cleaved by a furin endopeptidase丨Glycosylated

  • Subunit

    Interacts with SRPX2

  • SwissProt ID

    O75173

  • Synonyms

    ADAMTS-2; ADAMTS-4; ADMP-1

ADAMTS4 Antibody (YA7743)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • ADAMTS4 Antibody (YA7743)(PBS only) Product Image