ADAMTS4 Antibody (YA7743)

Cat. No.: HY-P88059: Data Sheet User Guide for Antibodies
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ADAMTS4 Antibody (YA7743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAMTS4.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ADAMTS4 Antibody (YA7743) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAMTS4.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O75173

Immunogen

Human recombinant protein fragment corresponding to amino acids 296-577 of human ADAMTS4 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease

Subcellular Localization：Secreted, extracellular space, extracellular matrix

Expression：
Tissue_Specificity: Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)
Induction: By IL1/interleukin-1

Isoforms & Post-Translational Modification：O75173 has two isomers: O75173-1: 90197 Da (predicted); O75173-2: 90065 Da (predicted).
The precursor is cleaved by a furin endopeptidase丨Glycosylated

Subunit：Interacts with SRPX2

Synonyms

ADAMTS-2; ADAMTS-4; ADMP-1

Documentation

User Guide for Antibodies (1077 KB)