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AF488-conjugated CD123 Antibody (6H6)

(Synonyms: CD123,CD123-AF488,6H6)

AF488-conjugated CD123 Antibody (6H6) is a Mouse-derived and AF488 conjugated monoclonal antibody, targeting to CD123.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    Mouse IgG1,κ

  • Application:

    FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.

  • Conjugation:
    AF488
  • AF488-conjugated CD123 Antibody (6H6) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
FC Info
FC: Flow Cytometry
Dilution Ratio 5 ul per 106 cells in a 100 µl suspension

Product Details

Description

AF488-conjugated CD123 Antibody (6H6) is a Mouse-derived and AF488 conjugated monoclonal antibody, targeting to CD123.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
Conjugation

AF488

Modification

Unmodified

Isotype

Mouse IgG1,κ

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.

  • Storage & Stability

    Stored at 2-8°C for 1 year, protect from light, do not freeze.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CD123 is a Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)[1].

  • Subcellular Localization

    Cell membrane

  • Isoforms & Post-Translational Modification

    CD123 has 2 isoforms, P26951-1: amino acid length is 378, molecular weight is 43330 Da (predicted); P26951-2: amino acid length is 300, molecular weight is 34466 Da (predicted).
    Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway.

  • Subunit

    Interacts with IL3.

  • Synonyms

    CD123,CD123-AF488,6H6

References

[1]. Huang S, et al. Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cells. 1999;17(5):265-72. [Content Brief]

AF488-conjugated CD123 Antibody (6H6) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • AF488-conjugated CD123 Antibody (6H6) Product Image