ALDH1A2 Antibody (YA9731)
(Synonyms: AL1A2_HUMAN, Aldehyde dehydrogenase family 1 member A2, ALDH1A2 aldehyde dehydrogenase 1 family, member A2, ALDH1A2, Aldh1a7, AV116159, MGC26444, RALDH 2, RALDH(II), Raldh1)
Based on 1 Customer Validation
ALDH1A2 Antibody (YA9731) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ALDH1A2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:200 | 1:200-1000 |
Product Details
ALDH1A2 Antibody (YA9731) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to ALDH1A2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
Synthetic peptide of Human ALDH1A2 (aa 1-50 / 518).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ALDH1A2 catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity)[1][2].
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Subcellular Localization
Cytoplasm
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Isoforms & Post-Translational Modification
ALDH1A2 has 4 isoforms, O94788-1: amino acid length is 518, molecular weight is 56724 Da (predicted); O94788-2: amino acid length is 480, molecular weight is 53060 Da (predicted); O94788-3: amino acid length is 497, molecular weight is 54673 Da (predicted); O94788-4: amino acid length is 422, molecular weight is 46137 Da (predicted).
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Subunit
Homotetramer
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SwissProt ID
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Synonyms
AL1A2_HUMAN, Aldehyde dehydrogenase family 1 member A2, ALDH1A2 aldehyde dehydrogenase 1 family, member A2, ALDH1A2, Aldh1a7, AV116159, MGC26444, RALDH 2, RALDH(II), Raldh1
Documentation
References
[1]. Chen Y, et al. Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 2018 Mar 16;13(3):582-590. [Content Brief]
[2]. Beecroft SJ, et al. Biallelic hypomorphic variants in ALDH1A2 cause a novel lethal human multiple congenital anomaly syndrome encompassing diaphragmatic, pulmonary, and cardiovascular defects. Hum Mutat. 2021 May;42(5):506-519. [Content Brief]
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