APC-conjugated CD279(PD-1) Antibody (29F.1A12)
(Synonyms: CD279(PD-1),CD279-APC,29F.1A12)APC-conjugated CD279(PD-1) Antibody (29F.1A12) is a Rat-derived and APC conjugated monoclonal antibody, targeting to CD279 (PD-1).
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Host:
Rat
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Isotype:
Rat IgG2a,κ
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Application:
FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD279 (PD-1, PDCD1) is a classic immune checkpoint receptor primarily expressed on activated T cells, exhausted T cells, Tregs, and a subset of NK cells. By binding to PD-L1/PD-L2 and inhibiting TCR signaling, it suppresses T-cell proliferation and cytotoxic function; it serves as a key target in research concerning tumor immune escape, T-cell exhaustion, and immunotherapy.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Subunit
Monomer. Interacts with CD274/PDCD1L1. Interacts with FBXO38; leading to ubiquitination and degradation of PDCD1 by the proteasome
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Synonyms
CD279(PD-1),CD279-APC,29F.1A12
Documentation
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