APC-conjugated CD62L Antibody (MEL-14)
(Synonyms: CD62L,CD62L-APC,MEL-14)APC-conjugated CD62L Antibody (MEL-14) is a Rat-derived and APC conjugated monoclonal antibody, targeting to CD62L.
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Host:
Rat
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Isotype:
Rat IgG2a,κ
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Application:
FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
APC
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
APC-conjugated CD62L Antibody (MEL-14) is a Rat-derived and APC conjugated monoclonal antibody, targeting to CD62L.
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Host Rat
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Clonality Monoclonal
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Species ReactivityMouse
APC
Unmodified
Rat IgG2a,κ
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD62L (L-selectin, SELL) is a leukocyte adhesion molecule that primarily mediates the homing of immune cells to lymph nodes and the rolling of cells along blood vessel walls. CD62L is a key marker for distinguishing between naive T cells, central memory T cells, and effector memory T cells, and it plays a significant role in research regarding T-cell immunological memory, vaccine development, CAR-T cell engineering, inflammatory cell trafficking, and immune cell differentiation.
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Expression
Tissue_specificity:Expressed in B-cell lines and T-lymphocytes -
Isoforms & Post-Translational Modification
CD62L has 2 isomers: P14151-1: 42187 Da (predicted); P14151-2: 43618 Da (predicted).
N-glycosylated -
Subunit
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding
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Synonyms
CD62L,CD62L-APC,MEL-14
Documentation
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